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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:bupivacaine pharmacodynamics pathway
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Accession:PW:0002194 term browser browse the term
Definition:The pathway of bupivacaine-target interaction and of the biochemical or physiological responses to drug. It acts mainly as a voltage-gated sodium channel blocker. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00393

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bupivacaine pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1A adrenoceptor alpha 1A ISO SMPDB SMP:00393 NCBI chr 8:24,884,187...24,985,824
Ensembl chr 8:24,885,741...24,983,125 		JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 ISO SMPDB SMP:00393 NCBI chr20:17,319,440...17,351,054
Ensembl chr20:17,315,117...17,351,054 		JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 ISO SMPDB SMP:00393 NCBI chr20:3,801,044...3,828,680
Ensembl chr20:3,802,887...3,828,692 		JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 ISO SMPDB SMP:00393 NCBI chr 6:36,166,586...36,195,343
Ensembl chr 6:36,166,262...36,195,363 		JBrowse link
G ATP1A4 ATPase Na+/K+ transporting subunit alpha 4 ISO SMPDB SMP:00393 NCBI chr20:3,759,509...3,794,106
Ensembl chr20:3,759,597...3,793,980 		JBrowse link
G ATP1B1 ATPase Na+/K+ transporting subunit beta 1 ISO SMPDB SMP:00393 NCBI chr25:59,898,745...59,925,166
Ensembl chr25:59,895,341...59,925,522 		JBrowse link
G ATP1B2 ATPase Na+/K+ transporting subunit beta 2 ISO SMPDB SMP:00393 NCBI chr16:7,030,016...7,035,620
Ensembl chr16:7,030,055...7,037,754 		JBrowse link
G ATP1B3 ATPase Na+/K+ transporting subunit beta 3 ISO SMPDB SMP:00393 NCBI chr15:48,691,224...48,742,336
Ensembl chr15:48,690,667...48,742,385 		JBrowse link
G ATP1B4 ATPase Na+/K+ transporting family member beta 4 ISO SMPDB SMP:00393
G CACNA1A calcium voltage-gated channel subunit alpha1 A ISO SMPDB SMP:00393 NCBI chr 6:11,883,353...12,307,023 JBrowse link
G CACNA2D2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 ISO SMPDB SMP:00393 NCBI chr22:11,751,026...11,891,407
Ensembl chr22:11,749,727...11,890,924 		JBrowse link
G CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 ISO SMPDB SMP:00393 NCBI chr16:66,971,379...66,994,031
Ensembl chr16:66,971,459...66,996,095 		JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit ISO SMPDB SMP:00393 NCBI chr 2:851,790...862,685 JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit ISO SMPDB SMP:00393 NCBI chr20:9,245,803...9,255,430
Ensembl chr20:9,247,231...9,253,795 		JBrowse link
G DRD1 dopamine receptor D1 ISO SMPDB SMP:00393 NCBI chr23:77,587,340...77,591,434 JBrowse link
G FXYD2 FXYD domain containing ion transport regulator 2 ISO SMPDB SMP:00393 NCBI chr 1:109,187,301...109,199,729
Ensembl chr 1:109,186,886...109,198,267 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 ISO SMPDB SMP:00393 NCBI chr12:1,020,556...1,050,568
Ensembl chr12:1,019,263...1,050,231 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A ISO SMPDB SMP:00393 NCBI chr 5:9,233,028...9,707,322
Ensembl chr 5:9,286,775...9,462,828 		JBrowse link
G GRIN3A glutamate ionotropic receptor NMDA type subunit 3A ISO SMPDB SMP:00393 NCBI chr12:37,700,311...37,865,390
Ensembl chr12:37,701,039...37,867,041 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A ISO SMPDB SMP:00393 NCBI chr 4:60,159,542...60,162,947
Ensembl chr 4:60,159,944...60,161,212 		JBrowse link
G KCND2 potassium voltage-gated channel subfamily D member 2 ISO SMPDB SMP:00393 NCBI chr21:89,091,939...89,575,464 JBrowse link
G KCNIP2 potassium voltage-gated channel interacting protein 2 ISO SMPDB SMP:00393 NCBI chr 9:94,854,024...94,873,655
Ensembl chr 9:94,855,403...94,873,312 		JBrowse link
G OPRM1 opioid receptor mu 1 ISO SMPDB SMP:00393 NCBI chr13:81,568,295...81,650,005
Ensembl chr13:81,568,732...81,625,088 		JBrowse link
G PCSK2 proprotein convertase subtilisin/kexin type 2 ISO SMPDB SMP:00393 NCBI chr 2:46,293,983...46,548,902
Ensembl chr 2:46,294,005...46,549,609 		JBrowse link
G POMC proopiomelanocortin ISO SMPDB SMP:00393 NCBI chr14:82,491,296...82,499,289
Ensembl chr14:82,494,323...82,499,447 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 ISO SMPDB SMP:00393 NCBI chr15:624,962...724,018
Ensembl chr15:625,742...721,963 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 ISO SMPDB SMP:00393 NCBI chr 6:29,962,993...29,972,845
Ensembl chr 6:29,962,843...29,973,325 		JBrowse link
G SLC6A2 solute carrier family 6 member 2 ISO SMPDB SMP:00393 NCBI chr 5:41,434,004...41,482,568
Ensembl chr 5:41,435,387...41,483,643 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 ISO SMPDB SMP:00393 NCBI chr 4:1,209,013...1,258,797
Ensembl chr 4:1,209,019...1,258,866 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 ISO SMPDB SMP:00393 NCBI chr16:23,929,196...23,969,665
Ensembl chr16:23,927,311...23,955,616 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4034
    drug pathway 383
      nervous system drug pathway 173
        anesthetic drug pathway 79
          bupivacaine drug pathway 30
            bupivacaine pharmacodynamics pathway 30
paths to the root